Effects of Benzothiadiazine Drugs on Carbohydrate Metabolism.

The administration of chlorothiazide both to man and to rats results in hyperglycemia following a glucose load. Its administration to rats causes a decreased rate of glucose utilization by their adipose tissue in vitro. Chlorothiazide added directly to the incubating medium also decreases the rate of glucose utilization of rat adipose tissue. These effects of chlorothiazide are most likely due to both a direct action of the drug on tissue glucose metabolism and an indirect effect which is the result of chlorothiazide causing a decrease in the level of serum insulin-like activity which in turn diminishes the activity of insulin-dependent enzymes involved in glucose metabolism.